Target Practice: Cellular Therapies, Side Effects, and Making Sense of the Acronyms

SELF STUDY / ENDURING - ESTIMATED TIME TO COMPLETE ACTIVITY: 51 Minutes

Overview

Explore the evolving landscape of cellular immunotherapies through a comprehensive review of CAR T-cell and tumor-infiltrating lymphocyte (TIL) therapies, including mechanisms of action, approved indications, emerging clinical trials, and key differences between treatment approaches. This activity highlights the immunologic principles underlying antigen recognition, T-cell activation, and cytokine signaling while emphasizing practical management of treatment-related toxicities such as cytokine release syndrome (CRS), ICANS, IL-2–related adverse effects, and Parkinsonian neurotoxicity associated with select CAR T-cell therapies. 

Target Audience

This CME initiative was designed for oncologists, surgeons, radiation oncologists, NPs, PAs, pharmacists, nurses, and other healthcare professionals involved in the treatment of patients with cancer.

Learning Objectives

  1. Describe the principles of CAR T cell therapy and TIL therapy to support informed clinical decision-making and patient education
  2. Explain the pathophysiology of cytokine release syndrome and evaluate strategies for its recognition and management 
  3. Recognize and manage neurologic toxicities associated with CAR T cell and TIL therapies, including ICANS, altered mentation, and Parkinsonian symptoms
  4. Identify and address less commonly discussed adverse effects related to CAR T cell and TIL therapies in clinical practice

 

Course summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit™

    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). Horizon CME is accredited by the ACCME to provide continuing medical education for physicians.

    Horizon CME designates this Enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Course opens: 
05/12/2026
Course expires: 
06/12/2027
Cost:
$0.00
Rating: 
0

Faculty

Tracy Farrell, PA-C

Senior Instructor, Department of Hematology 
University of Colorado
Aurora, CO

Tracy Farrell is a Physician Assistant and Senior Instructor in the Division of Hematology at the University of Colorado. She received her Bachelor Degree in Chemistry and Sociology from Creighton University. She then worked as a research assistant at the University of Nebraska Medical Center, working primarily with basic science cancer research. She then went to receive her Masters in Physician Assistant Studies at University of Nebraska Medical Center. Tracy's physician assistant career has been in malignant hematology, initially at the University of Nebraska, followed by the University of Colorado. She spends a lot of her spare time being injured from various sports and traveling.

Disclosures:

In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Horizon CME (HCME) ensures that continuing education activities are balanced, independent, objective, and scientifically rigorous. 

All persons in a position to influence the content of an accredited continuing education activity provided by Horizon CME are required to disclose to HCME any relevant financial relationships with ineligible companies within the past 24 months. All reported relevant financial relationships have been mitigated by Horizon CME.

Tracy Farrell, PA-C discloses no relevant financial relationships with any entity producing, marketing, re-selling, or distributing healthcare goods or services consumed by, or used on, patients during the past 24 months.

Available Credit

  • 0.75 AMA PRA Category 1 Credit™

    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME). Horizon CME is accredited by the ACCME to provide continuing medical education for physicians.

    Horizon CME designates this Enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Price

Cost:
$0.00
Please login or register to take this course.

There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:

  1. Read the CME/CE information and faculty disclosures.
  2. Participate in the online activity.
  3. Complete the post-test
  4. Submit the evaluation form

DISCLAIMER:

This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

Required Hardware/software

Access to the internet is required.

Supported Browsers:

Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above

Google Chrome 28.0+ for Windows, Mac OS, or Linux

Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux

Safari 6.0+ for Mac OSX 10.7 and above

 

Supported Phones & Tablets:

 Android 4.0.3 and above

iPhone/iPad with iOS 6.1 or above