Revolutionizing Leukemia Treatment: Allogeneic Transplants, Engineered T Cell Therapy, and Navigating the Complexities of GVHD
SELF STUDY / ENDURING - ESTIMATED TIME TO COMPLETE ACTIVITY: 75 Minutes
Overview
Participants will explore cutting-edge therapies in leukemia treatment, including allogeneic transplants' potential to trigger immune-mediated responses against leukemia. The session will also dive into the complexities of managing and preventing acute and chronic graft-versus-host disease (GVHD) and the challenges they post in patient care.
Target Audience
This CME initiative was designed for oncologists, surgeons, radiation oncologists, NPs, PAs, pharmacists, nurses, and other healthcare professionals involved in the treatment of patients with cancer.
Learning Objectives
1. Discuss the potential of an allogeneic transplant to mount an immune-mediated attack against leukemia in the recipient
2. Identify concepts behind engineered T cell therapy, and for what diseases are commercial CAR-T cells active
3. Describe challenges to the management and prevention of acute and chronic GVHD
Faculty
Gary Schiller, MD, FACP
Dr. Schiller is the Director of the Hematological Malignancy/ Stem Cell Transplant Program at the David Geffen School of Medicine at UCLA, supervising 200 transplants per year. He has extensive clinical research experience, having conducted many investigator-initiated and multicenter trials, mostly in Hematologic Malignancies as well as Blood and Marrow Transplantation. He is immediate past Chair of the Faculty Executive Committee for the School of Medicine at UCLA. He is an author of over 220 publications and 450 abstracts and presented in more than 350 events. He has mentored residents, medical students, and fellows for more than 30 years. He has also served as a member and Chair of the Committee on Training for the American Society of Hematology and worked with its Trainee Council developing programs for the national meeting of the Society and curriculum for its Trainee Day and is presently Chair of the ASH Foundation committee.
Dr. Schiller has an outstanding track record in clinical research, teaching, and mentoring and was co-investigator on Alternative Training grant for Bone Marrow Failure syndromes. He also has extensive experience outside of medicine, with nonprofit, charitable institutions. He has served on the Board of Trustees of Wilshire Boulevard Temple, and was Chairman of the Los Angeles Museum of the Holocaust. Dr. Schiller has 30 years of experience in the diagnosis and management of adults with Hematologic Malignancies and those undergoing allogeneic stem cell transplantation for non-malignant disorders including sickle cell disease.
Disclosures:
In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, Horizon CME (HCME) ensures that continuing education activities are balanced, independent, objective, and scientifically rigorous.
All persons in a position to influence the content of an accredited continuing education activity provided by Horizon CME are required to disclose to HCME any relevant financial relationships with ineligible companies within the past 24 months. All reported relevant financial relationships have been mitigated by Horizon CME.
Gary Schiller, MD FACP MD discloses contracted research with AbbVie, Actinium, Actuate, Agios, Arog, Astellas, Amgen, Aptevo, AltruBio, AVM Bio, BMS/ Celgene, Biopath, BioMea, Biosight, Cellularity, Celator, Constellation, Cogent, Cellectis, Daiichi-Sankyo, Deciphera, Delta-Fly, Fate, Forma, FujiFilm, Gamida, Genentech-Roche, Rigel Glycomimetics, Geron, Gilead, lncyte, Karyopharm, Kiadis, Kite/Gilead, Kronos Bio, Kura, Janssen, lmmunogene, Loxo, Marker, Mateen, Onconova, Pfizer, PrECOG, Regimmune, Samus, Sangamo, Sellas, Stemline, Syros, Takeda, Tolero, Trovagene, Agios, Amgen, Jazz, Orea, Ono-UK, Novartis, Cullinan, Consulting Fee’s with BMS, Curios and Daiichi Sankyo, Boxer Capital, Targeted Oncology, UJL Healthcare, Gather-ed, Med Exchange international, Acute Leukemia Forum, University of Maryland Speaker’s Bureau and Honoria with Agios, Jazz, Amgen, BMS Astellas, Seattle Genetics, Karyopharm, Rigel, Onlive and GSK. Advisory board with Axon Advisory, BMS and Stocks with Amgen, BMS and Janssen/J&J during the past 24 months.
Available Credit
- 1.00 AMA PRA Category 1 Credit™Horizon CME designates this Enduring activity for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
- 1.00 ANCCThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the American Nurses Credentialing Center’s Commission on Accreditation through the joint providership of the Nurse Practitioner Healthcare Foundation and Horizon CME. The Nurse Practitioner Healthcare Foundation is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation. NPHF is awarding the contact hours and is responsible for adherence to the ANCC criteria. Upon completion, NPs and RNs will be awarded up to 1.00 credit.
Price
There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:
- Read the CME/CE information and faculty disclosures.
- Participate in the online activity.
- Complete the post-test
- Submit the evaluation form
DISCLAIMER:
This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.
Required Hardware/software
Access to the internet is required.
Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above
Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above